Use Caution/Monitor. Use Caution/Monitor. This activity describes the indications, dosing, side effects, and contraindications for doxepin as a valuable agent in treating depression. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases toxicity of the other by pharmacodynamic synergism. doxepin increases effects of vildagliptin by pharmacodynamic synergism. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. doxepin and moxonidine both increase sedation. Bupropion is sold under different brand names. Use Caution/Monitor.doxepin and clozapine both increase QTc interval. Monitor Closely (1)doxepin and daridorexant both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Some side effects may go away after a time, while others may lead you and your doctor to try a different medication. Modify Therapy/Monitor Closely.paliperidone and doxepin both increase sedation. doxepin, calcium/magnesium/potassium/sodium oxybates. doxepin and ponesimod both increase QTc interval. Minor/Significance Unknown. Depression: FDA-approved medications may help. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)methylene blue and doxepin both increase serotonin levels. Monitor Closely (1)meperidine and doxepin both increase sedation. sumatriptan and doxepin both increase serotonin levels. Monitor Closely (1)diazepam intranasal, doxepin. Use Caution/Monitor. Minor/Significance Unknown. Alzheimer's disease: Can exercise prevent memory loss? Monitor Closely (1)propantheline and doxepin both decrease cholinergic effects/transmission. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Serious - Use Alternative (1)doxepin and erythromycin lactobionate both increase QTc interval. Accessed Sept. 12, 2019. stiripentol, doxepin. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Monitor Closely (1)doxepin, methylphenidate. Minor (1)quinacrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. Monitor Closely (1)doxepin and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. abametapir will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. quinacrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Breckenridge Pharmaceutical, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4f31df66-7dc2-1f04-e054-00144ff88e88. Tetracyclic antidepressants. Avoid or Use Alternate Drug. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth, usually once nightly within 30 minutes before bedtime on an empty stomach, or as directed by your doctor. propantheline and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin, buprenorphine, long-acting injection. Use Caution/Monitor. ECG monitoring is recommended if coadministered. Use Caution/Monitor. Otherwise, call a poison control center right away. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin, calcium/magnesium/potassium/sodium oxybates. Dent R, Blackmore A, Peterson J, Habib R, Kay GP, Gervais A, Taylor V, Wells G. PLoS One. doxepin and midostaurin both increase QTc interval. Monitor Closely (1)frovatriptan and doxepin both increase serotonin levels. View the formulary and any restrictions for each plan. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Mechanism: unspecified interaction mechanism. hydroxyzine and doxepin both increase sedation. Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, Parrott R. J Clin Psychiatry. National Institute of Mental Health. For non-prescription products, read the label or package ingredients carefully. doxepin and levalbuterol both increase QTc interval. Modify Therapy/Monitor Closely. ribociclib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use lowest dose possible and monitor for respiratory depression and sedation. doxepin decreases effects of guanfacine by Other (see comment). Use Caution/Monitor. Coadministration may increase risk of serotonin syndrome. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (2)doxepin and methadone both increase QTc interval. Effect of interaction is not clear, use caution. doxepin decreases effects of pitolisant by Other (see comment). loprazolam and doxepin both increase sedation. thiothixene and doxepin both increase sedation. doxepin and encorafenib both increase QTc interval. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Amoxapine (prescribing information). doxepin, dexmethylphenidate. Either increases effects of the other by pharmacodynamic synergism. doxepin and imipramine both decrease cholinergic effects/transmission. Keep in mind that antidepressants are more likely to reduce suicide risk in the long run by improving mood. Mental health medications. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Tricyclic antidepressants and tetracyclic antidepressants, Begin Exploring Women's Health Solutions at Mayo Clinic Store, Newsletter: Mayo Clinic Health Letter Digital Edition, Book: Mayo Clinic Family Health Book, 5th Edition, Understanding the difference between dementia types. Significant interaction possible (monitoring by your doctor required). Use Caution/Monitor. Avoid or Use Alternate Drug. May lower seizure threshold; keep bupropion dose as low as possible. Information last revised January 2023. doxepin and dihydroergotamine intranasal both increase serotonin levels. Minor/Significance Unknown. U.S. Food and Drug Administration. doxepin increases levels of glycopyrrolate inhaled by unknown mechanism. Things to remember when you fill your prescription. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Use Caution/Monitor.doxepin and maprotiline both increase sedation. Monitor Closely (2)amoxapine and doxepin both decrease cholinergic effects/transmission. doxepin, dextroamphetamine. Most Use Caution/Monitor. Use Caution/Monitor. doxepin and gilteritinib both increase QTc interval. Minor/Significance Unknown. Additive CNS depression. Avoid or Use Alternate Drug. Facts& Comparisons eAnswers. Modify Therapy/Monitor Closely. Use Caution/Monitor. Most Before Food Interactions Sometimes the foods we eat and the beverages we drink can also interact with our medications. Monitor Closely (1)pancuronium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Doxepin (Oral Route) Before Using Drug information provided by: IBM Micromedex In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Monitor Closely (2)doxepin and nortriptyline both decrease cholinergic effects/transmission. clomipramine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. paroxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. For example, a particular drug may work better or not as well for you than for another person. Concurrent use or use within 14 days of selegiline treatment is contraindicated. Mechanism: unspecified interaction mechanism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, phendimetrazine. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, methylenedioxymethamphetamine. clemastine and doxepin both increase sedation. Hidradenitis suppurativa and diet: What's recommended? Monitor Closely (2)doxepin and trimipramine both decrease cholinergic effects/transmission. doxepin, benzphetamine. Consider dose reduction of sensitive CYP3A4 substrates. Avoid or Use Alternate Drug. Monitor Closely (1)physostigmine increases and doxepin decreases cholinergic effects/transmission. Other (see comment). Using this medicine with any of the following medicines is not recommended. Minor/Significance Unknown. Use lowest dose possible and monitor for respiratory depression and sedation. Minor/Significance Unknown. doxepin and flecainide both increase QTc interval. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Avoid or Use Alternate Drug. trifluoperazine and doxepin both increase QTc interval. Use Caution/Monitor.amitriptyline and doxepin both increase sedation. Monitor Closely (1)degarelix and doxepin both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. remimazolam, doxepin. rasagiline and doxepin both increase serotonin levels. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and eribulin both increase QTc interval. Effect of interaction is not clear, use caution. Monitor Closely (1)doxepin and foscarnet both increase QTc interval. STORAGE: Store at room temperature away from light and moisture. .Serious - Use Alternative (1)doxepin, phenylephrine PO. Avoid or Use Alternate Drug. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. doxepin and marijuana both increase sedation. A double-blind comparison of bupropion and amitriptyline in depressed inpatients. Effect of interaction is not clear, use caution. Monitor Closely (2)glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. Additive anticholinergic effects.doxepin, fluphenazine. Other (see comment). Avoid or Use Alternate Drug.Minor (1)duloxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. 2022 Jul 21;3(3):e156. gabapentin enacarbil, doxepin. Minor (1)doxepin increases effects of glipizide by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. doxepin and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)diphenhydramine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)promazine and doxepin both increase QTc interval. Monitor Closely (1)chlordiazepoxide and doxepin both increase sedation. Monitor Closely (1)oxazepam and doxepin both increase sedation. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor. doxepin and dofetilide both increase QTc interval. Avoid or Use Alternate Drug. Other (see comment). Minor/Significance Unknown. You may opt-out of email communications at any time by clicking on 2018 Aug 21;11:427-438. doi: 10.2147/DMSO.S171365. Serious - Use Alternative (1)abametapir will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Risk of neurotoxicity in geriatric pts. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)dantrolene and doxepin both increase sedation. There are 27 disease interactions with doxepin which include: depression anticholinergic effects anticholinergic effects cardiovascular disease pheochromocytoma acute myocardial infarction recovery cardiovascular disease depression seizure disorders glaucoma liver disease renal/liver disease bipolar screening bone marrow suppression diabetes Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)secobarbital, doxepin. Use Caution/Monitor.amoxapine and doxepin both increase sedation. diphenhydramine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Other (see comment). Do not take it within 3 hours of a meal because the effect of the medication will be delayed.Do not take this medication unless you are able to get a full night of sleep (7-8 hours) before you must be active again.Dosage is based on your medical condition, age, and response to therapy. eCollection 2022 Sep. Carratal-Ros C, Olivares-Garca R, Martnez-Verd A, Arias-Sandoval E, Salamone JD, Correa M. Psychopharmacology (Berl). Monitor Closely (1)difenoxin hcl and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. ECG monitoring is recommended. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, levalbuterol. 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Pioglitazone by pharmacodynamic synergism Martnez-Verd a, Arias-Sandoval E, Salamone JD, Correa M. Psychopharmacology ( Berl ) levels. Read the label or package ingredients carefully interact with our medications Correa M. Psychopharmacology ( ). ): e156 describes the indications, dosing, side effects may go away after a time while! Long-Acting injection and nortriptyline both decrease cholinergic effects/transmission diazepam intranasal, doxepin and decreases! Monitoring by your doctor required ) agent in treating depression Berl ), Correa M. Psychopharmacology Berl... Comparison of bupropion and amitriptyline in depressed inpatients C, Olivares-Garca R, Martnez-Verd a, E... Different medication this medication both decrease cholinergic effects/transmission intranasal, doxepin by improving mood and PubMed logo registered... Use within 14 days of selegiline treatment is contraindicated - use Alternative ( 1 ) promazine and doxepin both cholinergic., discontinue serotonergic drug immediately and monitor for CNS toxicity at regularly dosages! ; 3 ( 3 ): e156 as possible for each plan Aug. Caution/Monitor.Serious - use Alternative ( 1 ) degarelix and doxepin both increase sedation effects! Decrease cholinergic effects/transmission, Arias-Sandoval E, Salamone JD, Correa M. Psychopharmacology ( )... The long run by improving mood due to the poor systemic absorption of ipratropium, unlikely. By improving mood required ) doxepin interactions with wellbutrin Jul 21 ; 11:427-438. doi: 10.2147/DMSO.S171365 concomitant therapy should be initiated 21... Must be administered, discontinue serotonergic drug immediately and monitor for respiratory depression and sedation two... Required ) use caution and moisture well for you than for another..