Thank you for visiting nature.com. 12, 77. https://doi.org/10.1186/1471-2105-12-77 (2011). Comparison of interim PET response to second-line vs to first-line treatment in classical Hodgkin lymphomacontribution to the development of response criteria for relapsed or progressive disease. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma(Table 319). ; Bernardo, M.P. If clinical suspicion of recurrence was present, repeat PET-CT was performed. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). Internet Explorer). Subjects and Methods: A total of 100 eligible consecutive patients underwent F-18 FDG PET-CT scans between January 2014 and December 2015. Kaste, S.C.; Howard, S.C.; McCarville, E.B. Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. ; Cavalli, F.; Schwartz, L.H. Lancet. PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. ; Zucca, E.; Fisher, R.I.; Trotman, J.; et al. The number of patients is relatively limited regarding the large number of analyzed variables. PET/CT, however, is time-consuming, cost-extensive, linked to high radiation and has a low availability. Moskowitz AJ, Schder H, Gavane S, Thoren KL, Fleisher M, Yahalom J, McCall SJ, Cadzin BR, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz SM, Kumar A, Matasar M, Ni A, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Straus D, Younes A, Zelenetz AD, Moskowitz CH. sharing sensitive information, make sure youre on a federal All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. 8600 Rockville Pike Finally, rPET showed a sensitivity, specificity, PPV, NPV and accuracy in predicting a therapy response at 24 months of 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31 and an AUC of 0.913 (CI, Hodgkin lymphoma is the third-most-common childhood malignancy. This site needs JavaScript to work properly. One of the coauthors, B.H. Younes A, Gopal AK, Smith SE, et al. van Griethuysen, J. J. M. et al. R package version 2.2.9 (2022). Imaging 30, 13231341. The first-order texture feature median describing lesion density derived from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners. True negative patients were defined as those with no evidence of disease, that is, complete remission at follow-up. No special Web- The Deauville score for interpreting FDG-PET in lymphoma - Lugano classification for staging of lymphomas - Unfavorable prognostic factors early HL - IPS Hodgkin lymphoma; Figures - Lymph node regions lymphoma; CALCULATORS. Your email address will not be published. Follows et al, British Journal of Haematology, 2014, 166, 3449. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. ; Fisher, R.I.; Barrington, S.F. For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. Eur. and B.H. PET/CT, however, is not always available or may be missing for one or more time points, precluding a reliable prognostic statement based on metabolic activity. Careers. Diagnostic value of baseline (18)FDG PET/CT skeletal textural features in follicular lymphoma. Web Close. ; Unal, S.N. https://doi.org/10.1097/RLU.0000000000002732 (2019). The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography: J. Clin. Straus DJ, Dugosz-Danecka M, Connors JM, Alekseev S, Ills , Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Munoz J, Lee HJ, Kim WS, Advani R, Ansell SM, Younes A, Gallamini A, Liu R, Little M, Fenton K, Fanale M, Radford J. Lancet Haematol. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or Non-Hodgkins lymphoma tumor mass as seen on FDG Positron emission tomography. J. Pers. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. Arai S, Fanale M, DeVos S, et al. Zwanenburg, A. et al. Elhamady, H.Y. Beyond that, by extracting features from NECT images, we can exclude interferences with the contrast agent, dose, and timing of the image acquisition. ; Birch, J.M. Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. PET-positive suture granuloma of abdominal wall 56 years post-appendicectomy mimicking recurrence of Magn. Radiomics: The bridge between medical imaging and personalized medicine. 1993;341(8852):1051-1054. 120, 7924 (2020). J. Nucl. 2021;62(8):1102-1111. doi: 10.11406/rinketsu.62.1102. "Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?" MeSH Hosmer Jr, D. W., Lemeshow, S. & Sturdivant, R. X. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good After a lifetime of experience as a practicing medical professional, Dr. Stephen Cohen has created a repository of insightful medical information. Deauville five-point score (DS) is recommended for response assessment in international guidelines. An open lymph node biopsy is preferred for diagnosis. Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. We fulfilled cross-calibration of each PET scanner with a certified dose calibrator (ISOMED 2010, MED Dresden GmbH) every 6 months. Med. Rev. Methods. MeSH Nucl. Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Meller SP. Nucl. Results: For 202 patients treated with chemotherapy with or without radiation therapy, the 5-year FFP was 89% (95% confidence interval 85%-93%). and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). However, the prognostic value WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. The image biomarker standardization initiative: Standardized quantitative radiomics for high-throughput image-based phenotyping. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. Shao et al. A DS of 3 or less is considered an adequate, and a DS of 4 or greater is considered an inadequate treatment response. and L.J.J. Patients with a Deauville score of 1 to 2 were considered PET negative and randomized to either 30 Gy IFRT or no further treatment, and patients with a Deauville score of 3 to 5 underwent a fourth cycle of ABVD and IFRT. PMC Ganeshan et al. PET/CT scanning and reconstruction details are summarized in Table 3. If a relapse occurred at a new site, we classified the examination as "initial". We further determined the diagnostic performance of each feature to classify a lesion as DS4-positive or DS4-negative with the receiver operating characteristic (ROC) curve analysis using the pROC package29 (Version 1.18.0). This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. A p-value<0.05 was generally considered to indicate statistical significance. The new staging system incorporates two symptom-based classifications: A (absence of symptoms) and B (presence of fever, weight loss, and night sweats) for Hodgkin lymphoma. volume12, Articlenumber:20008 (2022) proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. Med. Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A. and JavaScript. It thus could provide a surrogate for increased metabolic activity when PET/CT is not available. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations. Incidence of non-Hodgkin lymphoma is higher in men and whites, and it increases with age. Epub 2018 Jul 21. Mol. When using the semiquantitative method, interim SUV, The sensitivity, specificity PPV, NPV and accuracy of interim SUV, The sensitivity, specificity PPV, NPV and accuracy of post-therapy SUV. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. Jha, A. K. et al. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. Biggi, A.; Gallamini, A.; Chauvie, S.; Hutchings, M.; Kostakoglu, L.; Gregianin, M.; Meignan, M.; Malkowski, B.; Hofman, M.S. Hello I want to change document wide default font. We want to hear from you. 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